Includes technologies from the cell and gene therapy space, including NK cells, stem cells, T cells, AAV, Adenovirus, CRISPR, DNA, Lentivirus, RNA and vaccinia.
A collaboration between the University of Pittsburgh and the University of Pennsylvania has led to the development of bait oligonucleotides that inhibit and reverse TDP-43 inclusions associated with ALS, FTD, and Alzheimer's Disease.
The University of Pittsburgh has developed a technology that enhances in vivo vasculogenic reprogramming using Tissue Nanotransfection (TNT) to deliver specific transcription factors.
University of Pittsburgh researchers have developed a novel type of Chimeric Antigen Receptor (CAR) T cell therapy that targets Age-associated B Cells (ABC) using synthetic signaling.
University of Pittsburgh researchers have developed a novel RNA biosensor named CUTS-1 (CFTR-UNC13A TDP-43 Loss of Function Sensor), capable of detecting TDP-43 dysfunction in cells.
University of Pittsburgh and University of Colorado Boulder researchers have developed regulatory T cell therapy to treat reperfusion injury following myocardial infarction (MI, i.
Scientists from University of Pittsburgh have developed a novel approach to target cancer cells through the insertion of a “suicide gene” (HSV1-tk) into key gene fusion areas of the cancer genome.
A University of Pittsburgh researcher is developing gene therapy for Prader-Willi syndrome (PWS). Developed using novel mini promoters to enhance gene expression and a PWS-minigene adeno-associated virus (AAV) vector, it may be possible to treat this neurodevelopmental disorder.
University of Pittsburgh researchers have developed a novel set of quality control standards for selecting human corneal stromal stem cells (CSSCs) with optimal regenerative capabilities.
University of Pittsburgh researchers have designed innovative nucleotide prodrugs that leverage boryl allyl phosphate groups to selectively target oxidative stress environments.
University of Pittsburgh researchers have identified genes which when silenced can improve glucose tolerance, insulin secretion and insulin sensitivity.
University of Pittsburgh researchers have developed an innovative approach to enhance the effectiveness of adoptive cell therapy for cancer treatment by redirecting glucose metabolism.
